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Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment

Heterogeneity and hierarchy inside probably the most primitive hematopoietic stem cell compartment. Hematopoietic stem cells (HSCs) have been extensively characterised primarily based on practical definitions decided by experimental transplantation into lethally irradiated mice. In mice, HSCs are heterogeneous with regard to self-renewal potential, in vitro colony-forming exercise, and in vivo conduct. We tried potential isolation …

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