Amyloid

Amyloid Beta Protein

Summary

Alzheimer’s illness (AD) pathogenesis is broadly believed to be pushed by the manufacturing and deposition of the β-amyloid peptide (Aβ). For a few years, investigators have been puzzled by the weak to nonexistent correlation between the quantity of neuritic plaque pathology within the human mind and the diploma of scientific dementia. Current advances in our understanding of the event of amyloid pathology have helped clear up this thriller. Substantial proof now signifies that the solubility of Aβ, and the amount of Aβ in numerous swimming pools, could also be extra carefully associated to illness state. The composition of those swimming pools of Aβ displays totally different populations of amyloid deposits, and has particular correlates with the scientific standing of the affected person. Imaging applied sciences, together with new amyloid imaging brokers primarily based on the chemical construction of histologic dyes, at the moment are making it attainable to trace amyloid pathology together with illness development within the residing affected person. Curiously, these approaches point out that the Aβ deposited in AD is totally different from that present in animal fashions. Generally, deposited Aβ is extra simply cleared from the mind in animal fashions, and doesn’t present the identical bodily and biochemical traits because the amyloid present in AD. This raises essential points concerning the event and testing of future therapeutic brokers.

Key phrases: Amyloid, β-Amyloid Precursor Protein, Aβ, oligomer, fibril

DESCRIPTION

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Normal description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly current within the vascular amyloid deposits. Aβ40 contains of C-terminal membrane insertion area. It exhibits structural transition from random coil to a α-helical construction in a water-micelle medium.
amyloid
amyloid

Software

Amyloid β Protein Fragment 1-40 has been used:

  • within the temperature primarily based conformational research utilizing Fourier rework infrared/differential scanning calorimetry (FT-IR/DSC) research
  • as a reference normal in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of sufferers with head trauma
  • as a element of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the foremost constituents of senile plaques and neurofibrillary tangles that happen within the hippocampus, neocortex, and amygdala of sufferers with Alzheimer′s illness.
Amyloid β Protein Fragment 1-40 (Aβ40) kinds cation primarily based ion channels.

Reconstitution

For maximal organic exercise, dilute the inventory in calcium-free PBS to 1 mg/ml and incubate at 37 °C for four days.

Different Notes

Lyophilized from 0.1% TFA in H2O

Beta Amyloid

MO22142 100 ul
EUR 522

beta Amyloid 40 protein

30R-3013 500 ug
EUR 392.4
Description: Purified recombinant beta Amyloid 40 protein

beta Amyloid 42 protein

30R-3014 500 ug
EUR 392.4
Description: Purified recombinant beta Amyloid 42 protein

beta Amyloid antibody

70R-10624 1 ml
EUR 831.6
Description: Affinity purified Chicken polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-12571 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

Beta Amyloid antibody

70R-51450 100 ul
EUR 344.4
Description: Purified Polyclonal Beta Amyloid antibody

beta Amyloid Antibody

35506-100ul 100ul
EUR 468

beta Amyloid antibody

20R-AR011 250 ul
EUR 457.2
Description: Rabbit polyclonal beta Amyloid antibody

beta Amyloid antibody

10R-7917 100 ug
EUR 386.4
Description: Mouse monoclonal beta Amyloid antibody

beta Amyloid antibody

10R-A124a 50 ug
EUR 1213.2
Description: Mouse monoclonal beta Amyloid antibody

beta-Amyloid antibody

22965-100ul 100ul
EUR 468

beta Amyloid antibody

70R-AR020 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

beta Amyloid antibody

70R-BR019 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody

Amyloid beta-Protein (1-43)

5-00662 4 x 1mg Ask for price

Amyloid beta-Protein (20-29)

5-00663 4 x 5mg Ask for price

Amyloid beta-Protein (29-40)

5-00665 4 x 1mg Ask for price

Amyloid beta-Protein (33-42)

5-00666 4 x 5mg Ask for price

Amyloid beta-Protein (42-1)

5-00667 4 x 1mg Ask for price

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