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Genome-wide DNA methylation profiling using Infinium assay

Genome-wide DNA methylation profiling utilizing Infinium® assay.

 

OBJECTIVE
Bisulfite sequence evaluation of particular person CpG websites inside genomic DNA is a robust method for methylation evaluation within the genome.
The main limitation of bisulfite-based strategies is parallelization. Each array and next-generation sequencing know-how are succesful of addressing this bottleneck. On this report, we describe the applying of Infinium® genotyping know-how to investigate bisulfite-converted DNA to concurrently question the methylation state of over 27,000 CpG websites from promoters of consensus coding sequences (CCDS) genes.
METHODS
We tailored the Infinium genotyping assay to readout an array of over 27,000 pairs of CpG methylation-specific question probes complementary to bisulfite-converted DNA. Two probes have been designed to every CpG website: a ‘methylated’ and an ‘unmethylated’ question probe.
The probe design assumed that every one underlying CpG websites have been ‘in section’ with the queried CpG website as a consequence of their shut proximity. Bisulfite conversion was carried out with a modified model of the Zymo EZ DNA Methylation™ package.
RESULTS
We utilized this know-how to measuring methylation ranges throughout a panel of 14 totally different human tissues, 4 Coriell cell strains and 6 most cancers cell strains.
We noticed that CpG websites inside CpG islands (CGIs) have been largely unmethylated throughout all tissues (~80% websites unmethylated, β < 0.2), whereas CpG websites in non-CGIs have been reasonably to extremely methylated (solely ~12% websites unmethylated, β < 0.2). Inside CGIs, solely roughly 3-6% of the loci have been extremely methylated; in distinction, exterior of CGIs roughly 25-40% of loci have been extremely methylated. Furthermore, tissue-specific methylation (variation in methylation throughout tissues) was far more prevalent in non-CGIs than inside CGIs.
CONCLUSIONS
Our outcomes display a genome-wide scalable array-based methylation readout platform that’s each extremely reproducible and quantitative. Within the close to future, this platform ought to allow the evaluation of lots of of 1000’s to tens of millions of CpG websites per pattern.
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abx098961-6ml 6 ml
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abx098962-12ml 12 ml
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AR1016 100mL (for 10000-15000 assays)
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Description: Ready-to-use biotin free reagent applicable for blocking ELISA plates

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SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent exercise in vitro and in vivo.

FLT3 (fms-related tyrosine kinase/Flk2/Stk-2) is a receptor tyrosine kinase (RTK) primarily expressed on hematopoietic cells. In blasts from acute myelogenous leukemia (AML) sufferers, 2 lessons of FLT3 activating mutations have been recognized: inside tandem duplication (ITD) mutations within the juxtamembrane area (25%-30% of sufferers) and level mutations within the kinase area activation loop (7%-8% of sufferers).
FLT3-ITD mutations are probably the most frequent molecular defect recognized in AML and have been proven to be an unbiased prognostic issue for decreased survival. FLT3-ITD is due to this fact a beautiful molecular goal for remedy.
SU11248 is a lately described selective inhibitor with selectivity for cut up kinase area RTKs, together with platelet-derived development issue receptors, vascular endothelial development issue receptors, and KIT.
We present that SU11248 additionally has potent exercise in opposition to wild-type FLT3 (FLT3-WT), FLT3-ITD, and FLT3 activation loop (FLT3-Asp835) mutants in phosphorylation assays. SU11248 inhibits FLT3-driven phosphorylation and induces apoptosis in vitro. As well as, SU11248 inhibits FLT3-induced VEGF manufacturing. The in vivo efficacy of SU11248 was investigated in 2 FLT3-ITD fashions: a subcutaneous tumor xenograft mannequin and a bone marrow engraftment mannequin. We present that SU11248 (20 mg/kg/d) dramatically regresses FLT3-ITD tumors within the subcutaneous tumor xenograft mannequin and prolongs survival within the bone marrow engraftment mannequin.
Pharmacokinetic and pharmacodynamic evaluation in subcutaneous tumors confirmed {that a} single administration of an efficacious drug dose potently inhibits FLT3-ITD phosphorylation for as much as 16 hours following a single dose. These outcomes counsel that additional exploration of SU11248 exercise in AML sufferers is warranted.

Age-associated traits of murine hematopoietic stem cells.

Little is understood of age-associated useful modifications in hematopoietic stem cells (HSCs). We studied growing old HSCs on the clonal stage by isolating CD34(-/low)c-Equipment(+)Sca-1(+) lineage marker-negative (CD34(-)KSL) cells from the bone marrow of C57BL/6 mice. A inhabitants of CD34(-)KSL cells progressively expanded as age elevated.
No matter age, these cells shaped in vitro colonies with stem cell issue and interleukin (IL)-Three however not with IL-Three alone. They didn’t kind day 12 colony-forming unit (CFU)-S, indicating that they’re primitive cells with myeloid differentiation potential.
An in vivo limiting dilution assay revealed that numbers of multilineage repopulating cells elevated twofold from 2 to 18 mo of age inside a inhabitants of CD34(-)KSL cells in addition to amongst unseparated bone marrow cells.
As well as, we detected one other compartment of repopulating cells, which differed from HSCs, amongst CD34(-)KSL cells of 18-mo-old mice. These repopulating cells confirmed much less differentiation potential towards lymphoid cells however retained self-renewal potential, as steered by secondary transplantation.
We suggest that HSCs progressively accumulate with age, accompanied by cells with much less lymphoid differentiation potential, because of repeated self-renewal of HSCs.

MAGIC RED CATHEPSIN L KIT (OKSA11293)

OKSA11293 25 Tests
EUR 693.6
Description: Description of target: MAGIC REDâ„¢ CATHEPSIN L KIT;Species reactivity: Human;Application: IF;Assay info: ;Sensitivity:

MAGIC RED CATHEPSIN L KIT (OKSA11294)

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EUR 1576.8
Description: Description of target: MAGIC REDâ„¢ CATHEPSIN L KIT;Species reactivity: Human;Application: IF;Assay info: ;Sensitivity:

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55R-1298 25 assays
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CaspGLOW? Red Active Caspase-3 Staining Kit

K193-25
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1177-3
EUR 810

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BT3000-MR 1 PC
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Pesticide Mix 3 Containing 15 Compounds in Acetonitrile

SPXPR-3 1ML
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CaspGLOW Red Active Caspase Staining Kit

55R-1297 25 assays
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Red Active Caspase-8 Staining Kit

K2054-100 100 assays
EUR 686.4

Red Active Caspase-8 Staining Kit

K2054-25 25 assays
EUR 285.6

Red Active Caspase-9 Staining Kit

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Red Active Caspase-9 Staining Kit

K2055-25 25 assays
EUR 285.6

CaspGLOW? Red Active Caspase Staining Kit

K190-100
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CaspGLOW? Red Active Caspase Staining Kit

K190-25
EUR 288

Caspase-8 IETD-R110 Fluorometric HTS Assay Kit

30012-3 1KIT
EUR 1952.4
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CaspGLOW Red Active Caspase 8 Staining Kit

55R-1299 25 assays
EUR 355.2
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CaspGLOW Red Active Caspase 9 Staining Kit

55R-1300 25 assays
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CaspGLOW? Red Active Caspase-8 Staining Kit

K198-100
EUR 627.6

CaspGLOW? Red Active Caspase-8 Staining Kit

K198-25
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K199-100
EUR 620.4

CaspGLOW? Red Active Caspase-9 Staining Kit

K199-25
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M-PK-104 6 reactions
EUR 234
Description: JBS Magic Triangle

Canadian Pesticide Mix 3 Containing 8 Compounds

CAN-CAN-3 1ML
EUR 258.78

Amplite™ Fluorimetric Caspase 3/7 Assay Kit *Red Fluorescence*

13504 100 tests
EUR 420

Caspase-3

MO15136 100 ug
EUR 559.2

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GT15044 100 ug
EUR 600

Recombinant Transmembrane Protease Serine 2 Protein, Partial

E80016
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E80017
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Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial

E80018
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Cell Meter™ Caspase 3/7 Activity Apoptosis Assay Kit *Red Fluorescence*

22797 100 Tests
EUR 367.2

Magic Clamp Universal Platform Mini

SHA1302 EACH
EUR 316.92

Cell Meter™ Live Cell Caspase 3/7 Binding Assay Kit *Red Fluorescence*

20101 25 Tests
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Caspase 3 antibody

70R-11558 100 ug
EUR 774
Description: Rabbit polyclonal Caspase 3 antibody

Caspase 3 antibody

70R-11638 100 ug
EUR 564
Description: Rabbit polyclonal Caspase 3 antibody

Caspase 3 antibody

70R-49456 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 3 antibody

Caspase 3 antibody

70R-49457 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 3 antibody

Caspase 3 antibody

70R-49458 100 ul
EUR 292.8
Description: Purified Polyclonal Caspase 3 antibody

Caspase 3 antibody

70R-33463 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 3 antibody

Caspase 3 antibody

70R-31075 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 3 antibody

Caspase 3 antibody

70R-31076 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 3 antibody

Caspase 3 antibody

70R-31077 100 ug
EUR 392.4
Description: Rabbit polyclonal Caspase 3 antibody

Caspase 3 antibody

70R-13844 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Caspase 3 antibody

Caspase 3 protein

30R-2319 25 units
EUR 278.4
Description: Purified recombinant Human Caspase 3 protein

Caspase 3 protein

30R-2327 25 units
EUR 337.2
Description: Purified recombinant Human Caspase 3 protein

Caspase 3 protein

30R-2329 25 units
EUR 337.2
Description: Purified recombinant Human Caspase 3 protein

Caspase 3 protein

30R-2414 5 ug
EUR 583.2
Description: Purified recombinant Human Caspase 3 protein

Caspase-3 Antibody

48562-100ul 100ul
EUR 399.6

Caspase-3 Antibody

48562-50ul 50ul
EUR 286.8

Caspase-3 Antibody

48658-100ul 100ul
EUR 399.6

Caspase-3 Antibody

48658-50ul 50ul
EUR 286.8

Caspase-3 Antibody

3445-002mg 0.02 mg
EUR 206.18
Description: Caspase-3 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-3 is synthesized as an inactive proenzyme that undergoes proteolytic cleavage by caspases 8, 9 and 10 to produce 2 subunits, termed p20 and p11. These subunits dimerize to form the active enzyme. Caspase-3 proteolytically cleaves and activates other proteins such as caspases 6, 7 and 9.

Caspase-3 Antibody

3445-01mg 0.1 mg
EUR 523.7
Description: Caspase-3 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-3 is synthesized as an inactive proenzyme that undergoes proteolytic cleavage by caspases 8, 9 and 10 to produce 2 subunits, termed p20 and p11. These subunits dimerize to form the active enzyme. Caspase-3 proteolytically cleaves and activates other proteins such as caspases 6, 7 and 9.

Caspase-3 Peptide

3445P 0.05 mg
EUR 197.7
Description: (IN) Caspase-3 peptide

Caspase 3 antibody

20R-2495 50 ug
EUR 337.2
Description: Rabbit polyclonal Caspase 3 antibody

Caspase 3 antibody

20R-CR013 50 ug
EUR 620.4
Description: Rabbit polyclonal Caspase 3 antibody

Caspase-3 Antibody

3138-100
EUR 430.8

Caspase-3 Antibody

3138-30T
EUR 175.2

Caspase 3 antibody

20R-1424 100 ug
EUR 937.2
Description: Rabbit polyclonal Caspase 3 antibody

Caspase 3 antibody

20R-1469 100 ug
EUR 781.2
Description: Rabbit polyclonal Caspase 3 antibody

Caspase 3 Antibody

21420-100ul 100ul
EUR 302.4

Caspase 3 Antibody

21420-50ul 50ul
EUR 224.4

Caspase-3 Antibody

25442-100ul 100ul
EUR 468

Caspase 3 Antibody

ABF6311 100 ug
EUR 525.6

Caspase 3 Antibody

DF6020 200ul
EUR 420

Caspase 3 Antibody

DF6879 200ul
EUR 420

 

 

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